Surfactant assisted magnetic dispersive micro solid phase extraction-HPLC as a straightforward and green procedure for preconcentrating and determining Caffeine, Lidocaine, and Chlorpromazine in biological and water samples

Magnetic dispersive micro solid-phase extraction as a proper and selective sample preparation was developed to extract clean up three drugs, including Caffeine (CAF), Lidocaine (LID), Chlorpromazine (CPZ), before determining by HPLC-DAD. Nickel-doped BiFeO3 synthesised using the sol–gel method magnetic sorbent core coated with tetraethyl orthosilicate (TEOS) enhance stability selectivity. In procedure, dispersed into acetonitrile disperser solvent sodium dodecyl sulphate (SDS) agent injecting solution analytes. Several influential factors in were evaluated an experimental design strategy. Under optimum conditions, displayed wide linearity concentration ranges of 20.8–365, 1.4–389, 2.7–355 ng mL−1 determine CAF, LID, CPZ suitable R2 between 0.9963 0.9971, respectively. Intra-day inter-day relative standard deviations 3.5–3.8 3.9–4.3%. LODs LOQs for determination lower than 6.3 20.8 mL−1. The is convenient analytes real water biological samples RSD (n = 3) recovery 3.0–4.3% 87.5–96.9%,